Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …

In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …

Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …

The immune landscape of a tumor is highly connected to patient prognosis and response to
treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) …

Human NK cells can be subdivided into various subsets based on the relative expression of
CD16 and CD56. In particular, CD56 bright CD16−/dim NK cells are the focus of interest …

HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

Chimeric antigen receptor (CAR) T cell therapy has emerged as one of the major
breakthroughs in cancer immunotherapy in the last decade. Outstanding results in …

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …