The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …

Sudden cardiac death (SCD) is one of the leading causes of death worldwide, usually
involving young people. SCD remains a critical public health problem accounting for …

Drug repositioning and the relevance of orphan drug designation for β-thalassemia is
reviewed. Drug repositioning and similar terms ('drug repurposing','drug reprofiling','drug …

Arrhythmias are a relatively common type of cardiovascular disease. Most cardiovascular
diseases are often accompanied by arrhythmias. In clinical practice, an electrocardiogram …

The solute carrier family 4 (SLC4) is an important protein responsible for the transport of
various ions across the cell membrane and mediating diverse physiological functions, such …

Sudden death is a rare event in the pediatric population but with a social shock due to its
presentation as the first symptom in previously healthy children. Comprehensive autopsy in …

Primary electrical heart diseases, often considered channelopathies, are inherited genetic
abnormalities of cardiomyocyte electrical behavior carrying the risk of malignant arrhythmias …

Cardiovascular diseases are the main cause of sudden cardiac death (SCD) in developed
and developing countries. Inherited cardiac channelopathies are linked to 5–10% of SCDs …

Inherited cardiovascular diseases are highly heterogeneous conditions with multiple genetic
loci involved. The application of advanced molecular tools, such as Next Generation …

Cenobamate (CNB) is the latest antiseizure medication (ASM) authorized for the treatment of
focal-onset seizures in adults. Although the precise mechanism of action of CNB is not yet …