Ghrelin is a gastric‐derived peptide hormone with demonstrated impact on alcohol intake
and craving, but the reverse side of this bidirectional link, that is, the effects of alcohol on the …

Ghrelin, an orexigenic hormone, has emerged as a critical biological substrate implicated in
drug reward. However, the response of the ghrelin system to opioid-motivated behaviors …

Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5%
of adults worldwide. Novel pathways of damage have been described during the last years …

The acylated peptide hormone ghrelin impacts a wide range of physiological processes but
is most well known for controlling hunger and metabolic regulation. Ghrelin requires a …

Highly palatable foods and substance of abuse have intersecting neurobiological, metabolic
and behavioral effects relevant for understanding vulnerability to conditions related to food …

Drug addiction causes constant serious health, social, and economic burden within the
human society. The current drug dependence pharmacotherapies, particularly relapse …

Preclinical and clinical studies have identified the ghrelin receptor [growth hormone
secretagogue receptor (GHSR) 1a] as a potential target for treating alcohol use disorder. A …

Aim The purpose of this brief narrative review is to address the complexities and benefits of
extending animal alcohol addiction research to the human domain, emphasizing Allostasis …

Compared to other medical disorders, including other brain diseases, the number of
medications approved for alcohol use disorder (AUD) is very small. Disulfiram, naltrexone …

There is a critical need to increase the armamentarium of medications for AUD. Human
laboratory studies may help screen and prioritize promising targets and compounds before …