Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
Diagnosis and treatment of early chronic obstructive lung disease (COPD)
Chronic obstructive lung disease (COPD) is responsible for substantial rates of mortality and
economic burden, and is one of the most important public-health concerns. As the disease …
economic burden, and is one of the most important public-health concerns. As the disease …
Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the …
F Maltais, L Bjermer, EM Kerwin, PW Jones… - Respiratory …, 2019 - Springer
Background Prospective evidence is lacking regarding incremental benefits of long-acting
dual-versus mono-bronchodilation in improving symptoms and preventing short-term …
dual-versus mono-bronchodilation in improving symptoms and preventing short-term …
Measuring disease activity in COPD: is clinically important deterioration the answer?
D Singh, GJ Criner, I Naya, PW Jones, L Tombs… - Respiratory …, 2020 - Springer
Given the heterogeneity of chronic obstructive pulmonary disease (COPD), personalized
clinical management is key to optimizing patient outcomes. Important treatment goals …
clinical management is key to optimizing patient outcomes. Important treatment goals …
Long-term outcomes following first short-term clinically important deterioration in COPD
IP Naya, L Tombs, H Muellerova, C Compton… - Respiratory …, 2018 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterized by varying
trajectories of decline. Information regarding the prognostic value of preventing short-term …
trajectories of decline. Information regarding the prognostic value of preventing short-term …
Clinically Important Deterioration (CID) and Ageing in COPD: A Systematic Review and Meta-Regression Analysis According to PRISMA Statement
GM Manzetti, J Ora, A Sepiacci, M Cazzola… - … Journal of Chronic …, 2023 - Taylor & Francis
Purpose Clinically important deterioration (CID) is a composite endpoint developed to
quantify the impact of pharmacological treatment in clinical trials for Chronic Obstructive …
quantify the impact of pharmacological treatment in clinical trials for Chronic Obstructive …
Treatment of COPD with long-acting bronchodilators: association between early and longer-term clinically important improvement
CF Vogelmeier, IP Naya, F Maltais… - … Journal of Chronic …, 2021 - Taylor & Francis
Introduction This post hoc analysis of the “Early MAXimization of bronchodilation for
improving COPD stability”(EMAX) trial investigated whether patients achieving early …
improving COPD stability”(EMAX) trial investigated whether patients achieving early …
Tiotropium reduces clinically important deterioration in patients with mild-to-moderate chronic obstructive pulmonary disease: A post hoc analysis of the Tie-COPD …
F Wu, C Dai, Y Zhou, Z Deng, Z Wang, X Li, S Chen… - Respiratory …, 2024 - Elsevier
Background Clinically important deterioration (CID) is a composite endpoint used to
holistically assess the complex progression of chronic obstructive pulmonary disease …
holistically assess the complex progression of chronic obstructive pulmonary disease …
Comparation of predictive value of CAT and change in CAT in the short term for future exacerbation of chronic obstructive pulmonary disease
L Lin, Q Song, W Cheng, C Liu, YY Zhao… - Annals of …, 2022 - Taylor & Francis
Purpose Our study aimed to compare the predictive value of the COPD Assessment Test
(CAT) score at baseline and short-term change in CAT for future exacerbations in chronic …
(CAT) score at baseline and short-term change in CAT for future exacerbations in chronic …
Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial
CF Vogelmeier, EM Kerwin… - Therapeutic …, 2020 - journals.sagepub.com
Rationale: Symptom relief is a key treatment goal in patients with chronic obstructive
pulmonary disease (COPD). However, there are limited data available on the response to …
pulmonary disease (COPD). However, there are limited data available on the response to …