Of the neurological disorders, none can claim a battery of therapeutic agents based upon as
rational a pharmacology as can Parkinson's disease. In this review, the clinical …

The contribution of the peripheral and central pharmacokinetic mechanisms of levodopa to
the pathogenesis of the motor fluctuations that complicate its long‐term administration was …

Pharmacokinetic and pharmacodynamic mechanisms for levodopa have been studied in
relation to the pathogenesis of the motor fluctuations which complicate advanced …

The US Environmental Protection Agency (EPA) is required to regulate a large number of
chemicals. To ensure safe and adequate guidelines, the EPA must base its regulations on …

Many patients with idiopathic Parkinson's disease treated with levodopa for more than five
years develop fluctuations in their clinical response to this drug. Such fluctuations may be …

The relationships between magnitude of response to orally administered
carbidopa/levodopa (CD/LD) and serum/cerebrospinal fluid (CSF) concentrations of …

Актуальность проблемы. Вегетативные кризы (ВК) или панические атаки (ПА)-самые
яркие проявления синдрома дезадаптации, чаще встречающиеся в рамках панического …

The principal peripheral pharmacokinetic parameters of the levodopa/carbidopa association
were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson …

Striatal dopamine availability in connection with the plasma levodopa levels was studied in
12 parkinsonian patients treated with optimal doses of levodopa. Three patients showedthe …

• To investigate further the role of growth hormone (GH) on the cerebral effects of levodopa,
human somatotropin (human growth hormone) was administered to four patients with …