Highlights●Why biofuels and bioproducts remain critical to society●What molecular
products can be made by biotechnology using available feedstocks●How new systems and …

If biomanufacturing can become a sustainable route for producing chemicals, it will provide
a critical step in reducing greenhouse gas emissions to fight climate change. However …

Bacterial fitness depends on adaptability to changing environments. In rich growth medium,
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Our knowledge of transcriptional responses to changes in nutrient availability comes
primarily from few well-studied transcription factors (TFs), often lacking an unbiased genome …

Adaptive laboratory evolution experiments provide a controlled context in which the
dynamics of selection and adaptation can be followed in real-time at the single-nucleotide …

Quantifying the contribution of individual molecular components to complex cellular
processes is a grand challenge in systems biology. Here we establish a general theoretical …

Growth rate maximization is an important fitness strategy for microbes. However, the wide
distribution of slow-growing oligotrophic microbes in ecosystems suggests that rapid growth …

The expression of metabolic proteins is controlled by genetic circuits, matching metabolic
demands and changing environmental conditions. Ideally, this regulation brings about a …

RNA polymerase (RNAP) is emblematic of complex biological systems that control multiple
traits involving trade-offs such as growth versus maintenance. Laboratory evolution has …