DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …

In addition to the devastating symptoms of dementia, Alzheimer's disease (AD) is
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Healthy aging is the process of preserving and enhancing one's independence, physical
and mental well-being, and overall quality of life. It involves the mental, emotional, and …

Background Growing evidence shows that epigenetic modifications play a role in
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …