The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …

TGF-β superfamily signaling pathways emerged with the evolution of multicellular animals,
suggesting that these pathways contribute to the increased diversity and complexity required …

The cellular and molecular events regulating the induction and tissue-specific differentiation
of endoderm are central to our understanding of the development and function of many …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

The generation of insulin-producing β-cells from human pluripotent stem cells is dependent
on efficient endoderm induction and appropriate patterning and specification of this germ …

We report the isolation and identification of a new mutation affecting pigment cell fate in the
zebrafish neural crest. Homozygous nacre (nac w2) mutants lack melanophores throughout …

Many genes are members of large families that have arisen during evolution through gene
duplication events. Our increasing understanding of gene organization at the scale of whole …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

Biological systems involving short-range activators and long-range inhibitors can generate
complex patterns. Reaction-diffusion models postulate that differences in signaling range …