Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

There have been significant recent advances in the understanding of the pathophysiology of
pulmonary hypertension, and a growing number of therapeutic agents have become …

Anthracyclines are among the most active drugs in breast cancer patients. We planned to
evaluate the early and 2-year modification of left ventricular ejection fraction (LVEF) and the …

Abstract Background/Aims: Pulmonary hypertension (PHT) has been reported to be high
among end-stage renal disease (ESRD) patients. This study evaluated PHT in ESRD …

Alzheimer's disease (AD) is thought to be caused by the accumulation of amyloid beta (Aβ)
peptide within the brain. Endothelin-converting enzyme-2 (ECE-2), which is expressed in …

Multiple sclerosis (MS) is a disease of the central nervous system characterized by patchy
areas of demyelination, inflammation, axonal loss and gliosis, and a diffuse axonal …

The vascular endothelium is localized at the interface between the blood and surrounding
tissues, playing a pivotal role in the maintenance of tissue-fluid homeostasis and in the …

Endothelins including its most abundant isoform, endothelin-1 (ET-1), are peptides acting as
vasoconstrictors when binding to ET A and ET B receptors, and, in addition to their distinct …

Pulmonary arterial hypertension (PAH), also known as Group 1 Pulmonary Hypertension
(PH), is a PH subset characterized by pulmonary vascular remodeling and pulmonary …

Pulmonary arterial hypertension (PAH) is a complex disease with a poor prognosis. In recent
years, great advances have occurred in our understanding of the pathophysiologic …