The application of DNA and RNA G-quadruplexes to therapeutic medicines
GW Collie, GN Parkinson - Chemical Society Reviews, 2011 - pubs.rsc.org
The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …
repeat sequences have made four-stranded G-quadruplex structures the focus of both basic …
Conformational changes of non-B DNA
J Choi, T Majima - Chemical Society Reviews, 2011 - pubs.rsc.org
In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …
The structures of quadruplex nucleic acids and their drug complexes
S Neidle - Current opinion in structural biology, 2009 - Elsevier
Quadruplex nucleic acids are four-stranded structures formed from short tracts of G-rich
sequence associating together. Their formation from eukaryotic telomeric DNA sequences is …
sequence associating together. Their formation from eukaryotic telomeric DNA sequences is …
Molecular engineering of guanine-rich sequences: Z-DNA, DNA triplexes, and G-quadruplexes
O Doluca, JM Withers, VV Filichev - Chemical reviews, 2013 - ACS Publications
Guanine's array of hydrogen bond donors and acceptors lead it to take part in structures as
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …
Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
Previous studies have demonstrated that nuclease hypersensitivity regions of several proto-
oncogenic DNA promoters, situated upstream of transcription start sites, contain guanine …
oncogenic DNA promoters, situated upstream of transcription start sites, contain guanine …
Comprehensive analysis of intramolecular G-quadruplex structures: furthering the understanding of their formalism
M Farag, L Mouawad - Nucleic Acids Research, 2024 - academic.oup.com
Abstract G-quadruplexes (G4) are helical structures found in guanine-rich DNA or RNA
sequences. Generally, their formalism is based on a few dozen structures, which can …
sequences. Generally, their formalism is based on a few dozen structures, which can …
Guanine base stacking in G-quadruplex nucleic acids
G-quadruplexes constitute a class of nucleic acid structures defined by stacked guanine
tetrads (or G-tetrads) with guanine bases from neighboring tetrads stacking with one another …
tetrads (or G-tetrads) with guanine bases from neighboring tetrads stacking with one another …
[HTML][HTML] Structural motifs and intramolecular interactions in non-canonical G-quadruplexes
J Jana, S Mohr, YM Vianney, K Weisz - RSC Chemical Biology, 2021 - pubs.rsc.org
Guanine (G)-rich DNA or RNA sequences can assemble or intramolecularly fold into G-
quadruplexes formed through the stacking of planar G· G· G· G tetrads in the presence of …
quadruplexes formed through the stacking of planar G· G· G· G tetrads in the presence of …
G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
The formation of a single G-quadruplex structure adopted by a promising 25 nt G-rich
vascular endothelial growth factor aptamer in a K+ rich environment was facilitated by …
vascular endothelial growth factor aptamer in a K+ rich environment was facilitated by …
Structure and conformational dynamics of a stacked dimeric G-quadruplex formed by the human CEB1 minisatellite
CEB1 is a highly polymorphic human minisatellite. In yeast, the size variation of CEB1
tandem arrays has been associated with the capacity of the motif to form G-quadruplexes …
tandem arrays has been associated with the capacity of the motif to form G-quadruplexes …