Synaptic plasticity forms and functions
JC Magee, C Grienberger - Annual review of neuroscience, 2020 - annualreviews.org
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …
been considered an important component of learning and memory. Computational and …
Concepts of artificial intelligence for computer-assisted drug discovery
X Yang, Y Wang, R Byrne, G Schneider… - Chemical …, 2019 - ACS Publications
Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides
opportunities for the discovery and development of innovative drugs. Various machine …
opportunities for the discovery and development of innovative drugs. Various machine …
The theory and neuroscience of cerebellar cognition
JD Schmahmann, X Guell, CJ Stoodley… - Annual review of …, 2019 - annualreviews.org
Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal
cerebellar transform and dysmetria of thought and the principles of organization of cerebral …
cerebellar transform and dysmetria of thought and the principles of organization of cerebral …
Neuromorphic learning, working memory, and metaplasticity in nanowire networks
Nanowire networks (NWNs) mimic the brain's neurosynaptic connectivity and emergent
dynamics. Consequently, NWNs may also emulate the synaptic processes that enable …
dynamics. Consequently, NWNs may also emulate the synaptic processes that enable …
Entorhinal cortex directs learning-related changes in CA1 representations
C Grienberger, JC Magee - Nature, 2022 - nature.com
Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For
instance, the learning of a reward site by rodents requires the development of an over …
instance, the learning of a reward site by rodents requires the development of an over …
Cerebellar contributions to the basal ganglia influence motor coordination, reward processing, and movement vigor
Both the cerebellum and the basal ganglia are known for their roles in motor control and
motivated behavior. These two systems have been classically considered as independent …
motivated behavior. These two systems have been classically considered as independent …
Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon
Basal ganglia play a central role in regulating behavior, but the organization of their outputs
to other brain areas is incompletely understood. We investigate the largest output nucleus …
to other brain areas is incompletely understood. We investigate the largest output nucleus …
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …
yet it achieves many operations common across memory systems. Recent advances have …
Re-evaluating circuit mechanisms underlying pattern separation
NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …
overlapping patterns of activity that represent sensory and motor information. Pattern …
Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control
The brain generates predictive motor commands to control the spatiotemporal precision of
high-velocity movements. Yet, how the brain organizes automated internal feedback to …
high-velocity movements. Yet, how the brain organizes automated internal feedback to …