Synaptic plasticity forms and functions

JC Magee, C Grienberger - Annual review of neuroscience, 2020 - annualreviews.org
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

Concepts of artificial intelligence for computer-assisted drug discovery

X Yang, Y Wang, R Byrne, G Schneider… - Chemical …, 2019 - ACS Publications
Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides
opportunities for the discovery and development of innovative drugs. Various machine …

The theory and neuroscience of cerebellar cognition

JD Schmahmann, X Guell, CJ Stoodley… - Annual review of …, 2019 - annualreviews.org
Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal
cerebellar transform and dysmetria of thought and the principles of organization of cerebral …

Neuromorphic learning, working memory, and metaplasticity in nanowire networks

A Loeffler, A Diaz-Alvarez, R Zhu, N Ganesh… - Science …, 2023 - science.org
Nanowire networks (NWNs) mimic the brain's neurosynaptic connectivity and emergent
dynamics. Consequently, NWNs may also emulate the synaptic processes that enable …

Entorhinal cortex directs learning-related changes in CA1 representations

C Grienberger, JC Magee - Nature, 2022 - nature.com
Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For
instance, the learning of a reward site by rodents requires the development of an over …

Cerebellar contributions to the basal ganglia influence motor coordination, reward processing, and movement vigor

J Yoshida, M Oñate, L Khatami, J Vera… - Journal of …, 2022 - Soc Neuroscience
Both the cerebellum and the basal ganglia are known for their roles in motor control and
motivated behavior. These two systems have been classically considered as independent …

Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon

LE McElvain, Y Chen, JD Moore, GS Brigidi… - Neuron, 2021 - cell.com
Basal ganglia play a central role in regulating behavior, but the organization of their outputs
to other brain areas is incompletely understood. We investigate the largest output nucleus …

The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit

MN Modi, Y Shuai, GC Turner - Annual review of neuroscience, 2020 - annualreviews.org
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control

X Wang, Z Liu, M Angelov, Z Feng, X Li, A Li… - Nature …, 2023 - nature.com
The brain generates predictive motor commands to control the spatiotemporal precision of
high-velocity movements. Yet, how the brain organizes automated internal feedback to …