▪ Abstract Airways are embedded in the mechanically dynamic environment of the lung. In
utero, this mechanical environment is defined largely by fluid secretion into the developing …

Airways hyperresponsiveness is a cardinal feature of asthma but remains unexplained. In
asthma, the airway smooth muscle cell is the key end-effector of bronchospasm and acute …

We present an image functional modeling approach, which synthesizes imaging and
mechanical data with anatomically explicit computational models. This approach is utilized …

Mechanical stress (MS) causes cytoskeletal (CSK) and phenotypic changes in cells. Such
changes in airway smooth muscle (ASM) cells might contribute to the pathophysiology of …

We hypothesized that structural airway remodeling contributes to airways
hyperresponsiveness (AHR) in asthma. Small, medium, and large airways were analyzed by …

Imaging of alveoli in situ has for the most part been infeasible due to the high resolution
required to discern individual alveoli and limited access to alveoli beneath the lung surface …

Expiratory flow limitation occurs when flow ceases to increase with increasing expiratory
effort. The equal pressure point concept has been largely successful in providing intuitive …

Airway remodeling is an established feature of asthma. Histologic examination is essential
in the assessment of remodeling that is a pathologic concept. Examinations of autopsied or …

Optical coherence tomography is a rapidly maturing optical imaging technology, enabling
study of the in vivo structure of lung tissue at a scale of tens of micrometers. It has been used …

Airway smooth muscle (ASM) is cyclically stretched during breathing, even in the active
state, yet the factors determining its dynamic force-length behavior remain incompletely …