Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

During starvation the transcriptional activation of catabolic processes is induced by the
nuclear translocation and consequent activation of transcription factor EB (TFEB), a master …

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by
immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation …

Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …

Nitrate is both an important nutrient and a signalling molecule for plants. Although several
components of the nitrate signalling pathway have been identified, their hierarchical …

Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Recent studies have shown that the hypothalamus functions as a control center of aging in
mammals that counteracts age-associated physiological decline through inter-tissue …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …