Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for
many types of cancer. Genetic disparities between donor and host can result in immune …

Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects
many patients after allogeneic hematopoietic stem cell transplantation. Although we have …

Rhinovirus-induced neutrophil extracellular traps (NETs) contribute to acute asthma
exacerbations; however, the molecular factors that trigger NETosis in this context remain ill …

Challenges in haematopoietic stem cell transplantation such as low bone marrow (BM)
engraftment, graft versus host disease (GvHD) and the need for long-term …

Bone marrow is known as the site of hematopoiesis. What is not being described in
textbooks of immunology is the fact that bone marrow is not only a generative, but also an …

Persistent hypoxia in bone metastases induces an immunosuppressive environment,
limiting the effectiveness of immunotherapies. To address chronic hypoxia, we have …

Autologous stem cell transplantation (ASCT) is the standard of care consolidation therapy for
eligible patients with myeloma but most patients eventually progress, an event associated …

Bone marrow Treg cells (BM Tregs) orchestrate stem cell niches crucial for hematopoiesis.
Yet little is known about the molecular mechanisms governing BM Treg homeostasis and …

The cells of the innate immune system are the sentinels of tissue homeostasis, acting as 'first
responders' to cellular damage and infection. Although the complex interplay of different …

Lifestyle factors like poor maternal diet or antibiotic exposure disrupt early life microbiome
assembly in infants, increasing the risk of severe lower respiratory infections (sLRI). Our …