Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

It is well established that glial cells have critical roles in the inflammatory processes in the
central nervous system (CNS). These cells can be activated by a variety of endogenous and …

Significance: Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and
NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to …

The neurovascular unit (NVU) is involved in the pathological changes in Alzheimer's
disease (AD). The NVU is a structural and functional complex that maintains …

Self-assembling peptide-based hydrogels have become a highly attractive scaffold for three-
dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices …

Background To evaluate the role of NADPH oxidase-mediated reactive oxygen species
(ROS) production in multiple sclerosis pathogenesis, we examined the effects of apocynin …

Hypoglycemia, a common consequence of diabetes treatment, is associated with severe
morbidity and mortality and has become a major barrier to intensifying antidiabetic therapy …

Alzheimer's disease (AD) is a major neurodegenerative disease of old age, characterised by
progressive cognitive impairment, dementia and atrophy of the central nervous system. The …

Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's,
Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral …

Repurposing doxycycline for the treatment of amyloidosis has recently been put forward
because of the antiaggregating and anti-inflammatory properties of the drug. Most of the …