Alzheimer's disease (AD) is an irreversible age-related neurodegenerative disorder
clinically characterized by severe memory impairment, language deficits and cognitive …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme responsible for the
maintenance of genome stability, transcriptional regulation, and long-term potentiation in …

Radiotherapy (RT) plays a fundamental role in the treatment of glioblastoma (GBM). GBM
are notoriously invasive and harbor a subpopulation of cells with stem-like features which …

Amyloid-beta peptide accumulation in the brain is one of the main hallmarks of Alzheimer's
disease. The amyloid aggregation process is associated with the generation of free radical …

Background The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is required for
pro-inflammatory effects of TNFα. Our previous studies demonstrated that PARP-1 mediates …

Alzheimer's disease pathology includes, beside neuronal damage, reactive gliosis and
reduced blood-brain barrier (BBB) integrity. Microglia are intimately associated with the BBB …

Whole-exome sequencing of individuals with mild cognitive impairment, combined with
genotype imputation, was used to identify coding variants other than the apolipoprotein E …

Simple Summary Constant exposure to endogenous and environmental factors induces
oxidative stress and DNA damage. Rare brain disorders caused by defects in DNA repair …

NF-κB is a transcription factor that integrates pro-inflammatory and pro-survival responses in
diverse cell types. The activity of NF-κB is regulated in part by acetylation of its p65 subunit …

Abstract Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair
and gene expression. Excessive PARP1 hyperactivation, however, has been associated …