Our understanding of the progression and mechanisms underlying the onset of Parkinson's
disease (PD) has grown enormously in the past few decades. There is growing evidence …

Aging, a complex biological process, plays key roles the development of multiple disorders
referred as aging-related diseases involving cardiovascular diseases, stroke …

Type 2 diabetes is associated with adverse central nervous system effects, including a
doubled risk for Alzheimer's disease (AD) and increased risk of cognitive impairment, but the …

The hypothesis of enhanced vulnerability following perinatal asphyxia was investigated with
a protocol combining in vivo and in vitro experiments. Asphyxia-exposed (AS)(by 21 min …

Repurposing azithromycin has recently emerged as a promising strategy for the acute
treatment of ischemic stroke. The mechanism of neuroprotection depends on the ability of …

Fatal familial insomnia (FFI) is a dominantly inherited prion disease linked to the D178N
mutation in the gene encoding the prion protein (PrP). Symptoms, including insomnia …

Cerebral amyloid angiopathy (CAA) is characterized by the cerebrovascular amyloid-β (Aβ)
accumulation, and always accompanied by Alzheimer's disease (AD). The mechanisms …

Significance: Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and
NAD+-dependent signaling processes, which couples the enzymatic degradation of NAD+ …

The complex process of aging leads to a gradual deterioration in the function of cells,
tissues, and the entire organism, thereby increasing the risk of disease and death …

Eukaryotic organisms contain an enzyme family called poly (ADP-ribose) polymerases
(PARPs), which is responsible for the poly (ADP-ribosylation) of DNA-binding proteins …