The J20 mouse expresses human mutant amyloid-β protein precursor (hAβPPSwInd) and is
an established transgenic model of Alzheimer's disease (AD). From the age of 5 months …

Obesity is characterized by abnormal adipose tissue expansion and is associated with
chronic inflammation. Obesity itself may induce several comorbidities, including psychiatric …

Alzheimer's disease (AD) is an important public health problem which affects millions of
people worldwide. The major pathological hallmarks associated with AD are the …

Increasing evidence suggests that inflammation is one pathophysiological mechanism in
Alzheimer's disease (AD). Recent studies have identified an association between the poly …

Abstract Spinocerebellar ataxia type 7 (SCA7) is a cerebellar and retinal neurodegenerative
disease caused by a CAG/polyglutamine (polyQ) expansion mutation in the ataxin-7 …

Background: Inflammation is a major driver, and perhaps cause, of neurodegeneration,
suggesting neuroimmunomodulation as a therapeutic strategy. Microglia, the primary …

Radiotherapy (RT) plays a fundamental role in the treatment of glioblastoma (GBM). GBM
are notoriously invasive and harbor a subpopulation of cells with stem-like features which …

Die Alzheimer Krankheit ist pathophysiologisch durch extrazelluläre Ablagerungen des β-
Amyloid Peptids (Aβ) und intrazelluläre neurofibrilläre Bündel charakterisiert. Aβ entsteht …

Neurodegenerative disorder is the major age-related problem with no specific cure. The
drugs available in the market relieve the severity of the disease and increase the average …

Glutamate antibodies intranasally administered to Wistar rats at a dose of 300 μg/kg reduced
the elevated levels of expression of Aifml, Casp3, and Parp1 genes in the prefrontal cortex …