Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to
form a protective barrier that seals the wound and facilitates debris clearing, inflammatory …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Coupling is the process that links bone resorption to bone formation in a temporally and
spatially coordinated manner within the remodeling cycle. Several lines of evidence point to …

Coupling during bone remodeling refers to the spatial and temporal coordination of bone
resorption with bone formation. Studies have assessed the subtle interactions between …

The adult skeleton is a metabolically active organ system that undergoes continuous
remodeling to remove old and/or stressed bone (resorption) and replace it with new bone …

Imbalance of bone homeostasis induces bone degenerative diseases such as osteoporosis.
Hedgehog (Hh) signaling plays critical roles in regulating the development of limb and joint …

The coordination between bone resorption and bone formation plays an essential role in
keeping the mass and microstructure integrity of the bone in a steady state. However, this …

During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …