Acetylcholine (AC h) plays an important role in memory function and has been implicated in
aging‐related dementia, in which the impairment of hippocampus‐dependent learning …

Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Midbrain dopamine neurons are well known for their strong responses to rewards and their
critical role in positive motivation. It has become increasingly clear, however, that dopamine …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Rapidly growing empirical evidence supports the hypothesis that the cortex operates near
criticality. Although the confirmation of this hypothesis would mark a significant advance in …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

We have reviewed research on the effects of stress on LTP in the hippocampus, amygdala
and prefrontal cortex (PFC) and present new findings which provide insight into how the …

Studies on prefrontal cortex (PFC) dopamine (DA) function have revealed its essential role
in mediating a variety of cognitive and executive functions. A general principle that has …

Abstract Modafinil (2-[(Diphenylmethyl) sulfinyl] acetamide, Provigil) is an FDA-approved
medication with wake-promoting properties. Pre-clinical studies of modafinil suggest a …

Among the neuromodulators that regulate prefrontal cortical circuit function, the
catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful …