Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

The intestinal lumen contains an abundance of bacteria, viruses and fungi alongside
ingested material that shape the chronically active intestinal immune system from early life to …

Appropriate regulation of B cell differentiation into plasma cells is essential for humoral
immunity while preventing antibody-mediated autoimmunity; however, the underlying …

The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

The repetitive applications of vaccine boosters have been brought up in face of continuous
emergence of SARS-CoV-2 variants with neutralization escape mutations, but their …

Monoclonal antibodies (mAbs) have been used in the development of immunotherapies that
target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; …

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of
somatic hypermutation and proliferation in dark zones (DZs) and selection in light zones …

Long-term protective immunity to infectious disease depends on cell-mediated and humoral
immune responses. Induction of a strong humoral response relies on efficient B cell …

Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic
microenvironment but the cellular processes driving this are incompletely understood. Here …