Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Responding to the increased popularity of herbal medicines and other forms of
complementary or alternative medicine world-wide, this reference reviews and evaluates …

Alzheimer's disease is characterized by the deposition of senile plaques and progressive
dementia. The molecular mechanisms that couple plaque deposition to neural system …

Calcium handling by mitochondria is a key feature in cell life. It is involved in energy
production for cell activity, in buffering and shaping cytosolic calcium rises and also in …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by an
increase in amyloid metabolism. The calcium hypothesis of AD explores how activation of …

Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …

Substantial progress has been made toward understanding the neuropathology, genetic
origins, and epidemiology of neurodegenerative diseases, including Alzheimer's disease; …

Mutations in presenilins (PS) are the major cause of familial Alzheimer's disease (FAD) and
have been associated with calcium (Ca 2+) signaling abnormalities. Here, we demonstrate …

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging …