Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the
metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of
the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …

In a single vascular plant species, the ubiquitin system consists of thousands of different
proteins involved in attaching ubiquitin to substrates, recognizing or processing …

Mitophagy is a form of autophagy specialized to selectively remove mitochondria. Although
the PINK1/Parkin pathway is the best described mitophagy of damaged mitochondria …

Many essential biological processes are regulated through proximity, from membrane
receptor signaling to transcriptional activity. The ubiquitin-proteasome system controls …

Simple Summary Epstein-Barr Virus (EBV) infection is associated with various lymphomas
and carcinomas as well as other diseases in humans. The transmembrane protein LMP1 …