Background Hepatocellular carcinoma (HCC) is a common malignant tumor associated with
a poor prognosis. Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) has been reported to …

Chronic liver disease (CLD) is considered the leading cause of global mortality. In
westernized countries, increased consumption of alcohol and overeating foods with high …

SHARPIN (Shank-associated RH domain interacting protein) is the main component of the
linear ubiquitin chain activation complex (LUBAC). SHARPIN is involved in regulating …

Background Tamoxifen is the cornerstone of adjuvant therapy for hormone receptor-positive
breast cancer. Despite its efficacy, limited drug sensitivity and endocrine resistance remain …

Dilated (DCM) and ischemic cardiomyopathies (ICM) are associated with cardiac
remodeling, where the ubiquitin–proteasome system (UPS) holds a central role. Little is …

Abstract Regulation of Rho GTPases remains a topic of active investigation as they are
essential participants in cell biology and the pathophysiology of many human diseases. Non …

Liver regeneration represents an outstanding tool to study not only proliferation, but also
other important processes such as inflammation, regenerative response or stem cell biology …

The endoplasmic reticulum (ER) is an interconnected organelle that plays fundamental roles
in the biosynthesis, folding, stabilization, maturation, and trafficking of secretory and …

Ubiquitination is one of the most diverse forms of protein post-translational modification that
changes the function of the landscape of substrate proteins in response to stimuli, without …

The serine-threonine kinase Akt plays a fundamental role in cell survival, metabolism,
proliferation, and migration. To keep these essential processes under control, Akt activity …