Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …

Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain
unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as …

Because maturing oocytes and early embryos lack appreciable transcription,
posttranscriptional regulatory processes control their development. To better understand this …

Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …

The stability of mRNAs is regulated by signals within their sequences, but a systematic and
predictive understanding of the underlying sequence rules remains elusive. Here we …

MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …

As a key event for maintaining life cycles, reproduction is a central part of platyhelminth
biology. In case of parasitic platyhelminths, reproductive processes can also contribute to …

RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …

The CCR4–NOT deadenylase complex is a master regulator of translation and mRNA
stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs …