[HTML][HTML] The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L Zhang, CB Jackson, H Mou, A Ojha, ES Rangarajan… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral
spike (S) protein predominate over time in locales where it is found, implying that this …

COVID-19: A promising cure for the global panic

B Vellingiri, K Jayaramayya, M Iyer… - Science of the total …, 2020 - Elsevier
The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the
causative agent of a potentially fatal disease that is of great global public health concern …

[PDF][PDF] A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells

M Hoffmann, H Kleine-Weber, S Pöhlmann - Molecular cell, 2020 - cell.com
The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike
protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site …

[HTML][HTML] The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

[HTML][HTML] Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to
gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …

[HTML][HTML] Immune-mediated approaches against COVID-19

HF Florindo, R Kleiner, D Vaskovich-Koubi… - Nature …, 2020 - nature.com
Abstract The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The long incubation period of this new virus, which …

The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

M Hoffmann, H Kleine-Weber, N Krüger, M Müller… - BioRxiv, 2020 - biorxiv.org
The emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its
rapid national and international spread pose a global health emergency. Coronaviruses use …

[HTML][HTML] Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

R Bussani, E Schneider, L Zentilin, C Collesi, H Ali… - …, 2020 - thelancet.com
Background COVID-19 is a deadly pulmonary disease with peculiar characteristics, which
include variable clinical course and thrombophilia. A thorough understanding of the …

[HTML][HTML] New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

Y Hou, J Zhao, W Martin, A Kallianpur, MK Chung… - BMC medicine, 2020 - Springer
Abstract Background Coronavirus Disease 2019 (COVID-19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has now been confirmed worldwide …

[PDF][PDF] Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses

R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …