Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
SARS-CoV-2 main protease drug design, assay development, and drug resistance studies
Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
Protein structure and sequence reanalysis of 2019-nCoV genome refutes snakes as its intermediate host and the unique similarity between its spike protein insertions …
As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia
epidemic, the careful analysis of its transmission and cellular mechanisms is sorely needed …
epidemic, the careful analysis of its transmission and cellular mechanisms is sorely needed …
Proteolytic activation of SARS‐CoV‐2 spike protein
M Takeda - Microbiology and immunology, 2022 - Wiley Online Library
Spike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this
process is discussed, with particular focus on the novel coronavirus, severe acute …
process is discussed, with particular focus on the novel coronavirus, severe acute …
Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
[HTML][HTML] Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits
viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies …
viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies …
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
Trends and strategies to combat viral infections: A review on FDA approved antiviral drugs
DR Tompa, A Immanuel, S Srikanth… - International journal of …, 2021 - Elsevier
The infectious microscopic viruses invade living cells to reproduce themselves, and causes
chronic infections such as HIV/AIDS, hepatitis B and C, flu, etc. in humans which may lead to …
chronic infections such as HIV/AIDS, hepatitis B and C, flu, etc. in humans which may lead to …
SARS-CoV-2 antiviral therapy
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …
vaccination, as well as for those who do not respond robustly to vaccination. This review …