Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity
Y Zhu, D Yu, H Yan, H Chong, Y He - Journal of virology, 2020 - Am Soc Microbiol
ABSTRACT The 2019 coronavirus disease (COVID-19), caused by the emerging severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed serious threats to …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed serious threats to …
[HTML][HTML] Coronaviruses—drug discovery and therapeutic options
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43,
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …
Structure, function, and evolution of coronavirus spike proteins
F Li - Annual review of virology, 2016 - annualreviews.org
The coronavirus spike protein is a multifunctional molecular machine that mediates
coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its …
coronavirus entry into host cells. It first binds to a receptor on the host cell surface through its …
[HTML][HTML] The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status
YR Guo, QD Cao, ZS Hong, YY Tan, SD Chen… - Military medical …, 2020 - Springer
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously
known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout …
known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout …
[HTML][HTML] Virtual screening of natural products against type II transmembrane serine protease (TMPRSS2), the priming agent of coronavirus 2 (SARS-CoV-2)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused about 2 million
infections and is responsible for more than 100,000 deaths worldwide. To date, there is no …
infections and is responsible for more than 100,000 deaths worldwide. To date, there is no …
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …
[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy
Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …
SARS-CoV-2 main protease drug design, assay development, and drug resistance studies
Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the …
emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the …
[HTML][HTML] Human coronaviruses: a review of virus–host interactions
Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of
respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome …
respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome …