High levels of lactate are positively associated with the prognosis and mortality in patients
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …

The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct …

Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally
activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell …

Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1
and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They …

ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and
angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the …

Since the generation of cell-type specific knockout models, the importance of inter-cellular
communication between neural, vascular, and microglial cells during neural development …

Age-related and chemotherapy-induced bone loss depends on cellular senescence and the
cell secretory phenotype. However, the factors secreted in the senescent microenvironment …

Diabetes mellitus (DM) characterized by hyperglycemia is a chronic metabolic disorder that
leads to many symptoms and vascular complications. Despite the close association between …

Extracranial arteriovenous malformation (AVM) is a congenital vascular anomaly causing
disfigurement, bleeding, ulceration, and pain. Most lesions are associated with somatic …

Background: Pulmonary hypertension (PH) is a cancer-like proliferative disease, which has
no curative treatment options. The dysfunction of pulmonary artery endothelial cells plays a …