Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Purpose The initial results of the APL0406 trial showed that the combination of all-trans-
retinoic acid (ATRA) and arsenic trioxide (ATO) is at least not inferior to standard ATRA and …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

PML nuclear bodies are nucleated by the PML protein, which polymerizes into spherical
shells where it concentrates many unrelated partner proteins. Emerging data has connected …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Recent clinical trials have demonstrated that the immense majority of acute promyelocytic
leukemia (APL) patients can be definitively cured by the combination of two targeted …

Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Although acute promyelocytic leukemia (APL) is one of the most characterized forms of
acute myeloid leukemia (AML), the molecular mechanisms involved in the development and …

Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based nuclear structures that
regulate various cellular processes. SUMOylation, the process of covalently conjugating …