During million years, Nature has created a “wealthy repertoire of novel features.” These
features are frequently used in the fabric of artificial materials, referred to as “biomaterials.” …

Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …

Introduction High-grade gliomas (HGG) are the most common malignant primary brain
tumors in adults, with a median survival of~ 18 months. The standard of care (SOC) is …

Gliomas, which account for nearly a quarter of all primary CNS tumors, present significant
contemporary therapeutic challenges, particularly the highest-grade variant (glioblastoma …

Brain cancer is the most aggressive one among various cancers. It has a drastic impact on
people's lives because of the failure in treatment efficacy of the currently employed …

In recent years, many research groups have begun to utilize bioengineered in vitro models
of cancer to study mechanisms of disease progression, test drug candidates, and develop …

Glioblastoma, the deadliest form of primary brain tumor, remains a disease without cure.
Treatment resistance is in large part attributed to limitations in the delivery and distribution of …

Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents
about 60% of all adult primary brain tumors. It is notorious for its extremely low (~ 5%) 5-year …

Traditional tumor models cannot perfectly simulate the real state of tumors in vivo, resulting
in the termination of many clinical trials. 3D tumor models' technology provides new in vitro …

The translational potential of promising anticancer medications and treatments may be
enhanced by the creation of 3D in vitro models that can accurately reproduce native tumor …