Selective activation of peripheral κ opioid receptors (KORs) may overcome the dose-limiting
adverse effects of conventional opioid analgesics. We recently developed a vicinal disulfide …

Background In the present study we determined the role of transient receptor potential V1
channel (TRPV1) and acid-sensing ion channel 3 (ASIC3) in chronic nociception. Methods …

The role of 5-HT2A/2B/2C receptors in formalin-induced secondary allodynia and
hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors …

Orofacial pain is one of the most common medical challenges. A preliminary report indicates
that the NOP receptor may act as a therapeutic target in orofacial pain. Previous studies …

This study assessed the participation of spinal TWIK-related acid-sensitive K+ channels 1
and 3 (TASK-1 and TASK-3) in inflammatory (formalin test) and neuropathic (spinal nerve …

A bifunctional peptide containing an opioid and nociceptin receptor-binding
pharmacophore, H-Dmt-D-Arg-Aba-β-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2 (KGNOP1), was …

Pain is the non-motor symptom with the highest prevalence in patients with Parkinson's
Disease (PD) affecting 40–85%. This study aimed to investigate the development of tactile …

Transcutaneous electrical nerve stimulation (TENS) activates various pathways to induce
antinociceptive effects, based on the frequencies used. This study evaluates the preemptive …

The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves
the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis …

In this study, we employed a rodent model for persistent allodynia and hyperalgesia to
determine whether voluntary exercise could exert analgesic effects on these pain symptoms …