The embryonic program 'epithelial-mesenchymal transition'(EMT) is activated during tumor
invasion in disseminating cancer cells. Characteristic to these cells is a loss of E-cadherin …

Increasing evidence from animal and in vitro studies indicates that n− 3 fatty acids,
especially the long-chain polyunsaturated fatty acids eicosapentaenoic acid and …

Abstract Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of
prostaglandins. Very recently their role in carcinogenesis has become more evident. They …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Abstract Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor
invasion, metastasis, and poor prognosis in non–small cell lung cancer (NSCLC). Here, we …

Elevated tumor cyclooxygenase (COX-2) expression is associated with increased
angiogenesis, tumor invasion, and suppression of host immunity. We have previously shown …

The two isoforms cyclooxygenase-1 and-2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …

Several types of human tumors overexpress cyclooxygenase (COX)-2 but not COX-1, and
gene knockout transfection experiments demonstrate a central role of COX-2 in …

We investigated whether peroxisome proliferator-activated receptor γ (PPARγ) ligands
(ciglitazone, troglitazone, and 15-deoxy-Δ 12, 14 prostaglandin J 2) inhibited …