Recently, an inducible microsomal human prostaglandin E synthase (mPGES) was
identified. This enzyme converts the cyclooxygenase (COX) product prostaglandin (PG) H2 …

We investigated whether microtubule-interfering agents (MIAs: taxol, colchicine, nocodazole,
vinblastine, vincristine, 17-β-estradiol, 2-methoxyestradiol) altered cyclooxygenase-2 (COX …

Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and
experimental studies. Some bile acids stimulate growth of normal colonic and adenoma …

The antitumor effects of the selective cyclooxygenase (COX)-2 inhibitor SC-236 alone and in
combination with radiation were investigated using the human glioma cell line U251 grown …

Context.—Myofibroblasts are distinct cells with characteristics of both smooth muscle cells
and fibroblasts. Through their ability to secrete cytokines, chemokines, prostaglandins …

To fulfill their role in host-defense, granulocytes secrete chemically reactive oxidants,
radicals, and electrophilic mediators. While this is an effective way to eradicate pathogenic …

We immunohistochemically examined material from 36 pancreata (adenocarcinomas, 30
lesions; pancreatic intraepithelial neoplasia [PanIN], 65; normal pancreatic ducts, 30) for …

The modifying effects of dietary feeding of a polyisoprenylated benzophenone, garcinol,
isolated from Garcinia indica fruit rind on the development of azoxymethane (AOM)-induced …

Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has a protective effect on the
incidence of colon neoplasia. However, polymorphisms in NSAID-metabolizing enzymes …

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of different cancer cell
types, suggesting a broad role for their cyclooxygenase (COX) targets and eicosanoid …