Peroxisome proliferator-activated receptor-γ is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell …
M Wick, G Hurteau, C Dessev, D Chan, MW Geraci… - Molecular …, 2002 - ASPET
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of different cancer cell
types, suggesting a broad role for their cyclooxygenase (COX) targets and eicosanoid …
types, suggesting a broad role for their cyclooxygenase (COX) targets and eicosanoid …
Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal …
M Yao, W Zhou, S Sangha, A Albert, AJ Chang… - Clinical cancer …, 2005 - AACR
Purpose: To determine whether the nonselective and relatively inexpensive nonsteroidal
anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might …
anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might …
Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer
M Yao, EC Lam, CR Kelly, W Zhou, MM Wolfe - British journal of cancer, 2004 - nature.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to reduce the risk and
mortality of colorectal cancer (CRC) by inhibiting the activity of cyclooxygenase (COX). The …
mortality of colorectal cancer (CRC) by inhibiting the activity of cyclooxygenase (COX). The …
[PDF][PDF] Pharmacological and dietary factors in prevention of colorectal cancer
Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and fourth most
frequent reason of cancerrelated death throughout the world. About 70% of malignant …
frequent reason of cancerrelated death throughout the world. About 70% of malignant …
Nonsteroidal anti‐inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas
TK Asano, RS McLeod - Cochrane Database of Systematic …, 2004 - cochranelibrary.com
Background There is evidence from experimental animals studies, prospective and
retrospective observational studies that nonsteroidal anti‐inflammatory drugs (NSAIDS) may …
retrospective observational studies that nonsteroidal anti‐inflammatory drugs (NSAIDS) may …
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering
N Vunnam, MC Young, EE Liao, CH Lo… - Cancer Biology & …, 2023 - Taylor & Francis
Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor
and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and …
and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and …
Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer
A Hartwich, S Konturek, P Pierzchalski… - International journal of …, 2001 - Springer
Helicobacter pylori (HP) infection is usually accompanied by an increased plasma level of
gastrin, a potent mitogen able to induce cyclooxygenase (COX)-2. This study examined (a) …
gastrin, a potent mitogen able to induce cyclooxygenase (COX)-2. This study examined (a) …
Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice
S Sánchez-Fidalgo, I Villegas, A Cárdeno, E Talero… - Clinical Nutrition, 2010 - Elsevier
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) are at increased
risk for developing ulcerative colitis (UC)-associated colorectal cancer (CRC). Several …
risk for developing ulcerative colitis (UC)-associated colorectal cancer (CRC). Several …
In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations
U Raju, E Nakata, P Yang, RA Newman, KK Ang… - International Journal of …, 2002 - Elsevier
Purpose: Selective cyclooxygenase-2 inhibitors have been reported to enhance the tumor
response to radiation in vivo, but the cellular mechanisms underlying the radiosensitizing …
response to radiation in vivo, but the cellular mechanisms underlying the radiosensitizing …
Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-α in normal and malignant prostate cells
V Subbarayan, AL Sabichi, N Llansa, SM Lippman… - Cancer research, 2001 - AACR
Abstract Cyclooxygenase (COX)-2 expression is elevated in some malignancies; however,
information is scarce regarding COX-2 contributions to the development of prostate cancer …
information is scarce regarding COX-2 contributions to the development of prostate cancer …