Psoriasis is a chronic inflammatory skin disorder, and current treatments include topical
therapies, phototherapy, systemic immune modulators, and biologics, aiming to alleviate …

Background: Hidradenitis suppurativa (HS), also known as acne inversa or Verneuil's
disease, is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair …

The JAK-STAT signaling pathway mediates important cellular processes such as immune
response, carcinogenesis, cell differentiation, division and death. Therefore, drugs that …

Autoimmune bullous disease (AIBD) is a severe skin disorder caused by autoantibodies that
target intercellular or cell-matrix adhesion proteins. Currently, the preferred treatment for …

Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …

The introduction of biologic therapies has led to dramatic improvements in the management
of moderate-to-severe psoriasis. Even though the efficacy and safety of the newer biologic …

Introduction Numerous cutaneous dermatoses mediated by cytokines depend on the JAK
STAT pathway for intracellular signaling. JAK inhibitors form a useful therapeutic approach …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate
signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other …

Background Orally administered small-molecule drugs including tyrosine kinase 2 (TYK2)
inhibitors and phosphodiesterase 4 (PDE4) inhibitors are new candidates for systemic …

JAK inhibitors target specific inflammatory cytokines involved in various inflammatory
diseases. Four molecules have been approved for dermatological use: upadacitinib …