Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an
essential coenzyme for metabolic activity, causes various age-related diseases and …

The progressive and generalized loss of skeletal muscle mass and function, also known as
sarcopenia, underlies disability, increasing adverse outcomes and poor quality of life in …

Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating
input from the hypothalamic master clock and intracellular metabolic signals. One such key …

BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells
(MuSCs) that influences the functional and regenerative capacity of skeletal muscle …

Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to the
timing of intake. We recently found that intermittent once-weekly prednisone improved …

The process of tissue regeneration occurs in a developmentally timed manner, yet the role of
circadian timing is not understood. Here, we identify a role for the adult muscle stem cell …

The nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor, involved in
various physiological and molecular processes, including energy metabolism, epigenetics …