Background: Inflammation is a part of the first line of defense of the body against invasive
pathogens, and plays a crucial role in tissue regeneration and repair. A proper inflammatory …

Microglia, of myeloid origin, play fundamental roles in the control of immune responses and
the maintenance of central nervous system homeostasis. These cells, just like peripheral …

Neuroinflammation is associated with a broad spectrum of neurodegenerative and
psychiatric diseases. The core process in neuroinflammation is activation of microglia, the …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Pathological
proteins of AD mainly contain amyloid-beta (Aβ) and tau. Their deposition will lead to neuron …

Over the past three decades, there has been constant postulation regarding the infectious
etiology of Alzheimer disease (AD), which in turn suggests the vital role of various infectious …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

A brain-targeting nanodelivery system has been a hot topic and has undergone rapid
progression. However, due to various obstacles such as the intestinal epithelial barrier (IEB) …

This longitudinal study sought to determine whether the 18 kDa translocator protein (TSPO),
a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron …

Dopamine (DA) is a neurotransmitter in the central nervous system as well as in peripheral
tissues. Emerging evidence however points to DA also as a key transmitter between the …