In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Female fertility is inversely correlated with maternal age due to a depletion of the oocyte
pool and a reduction in oocyte developmental competence. Few studies have addressed the …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Photobiomodulation with 808 nm laser light electively stimulates Complexes III and IV of the
mitochondrial respiratory chain, while Complexes I and II are not affected. At the wavelength …

Oxidative stress (OS), which arises through an imbalance between the formation of reactive
oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of …

Perfluorononanoic acid (PFNA), a member of PFAS, is frequently detected in human blood
and tissues, even in follicular fluid of women. The exposure of PFNA, but not PFOA and …

The number of mitochondria in the oocyte along with their functions (eg, energy production,
scavenger activity) decline with age progression. Such multifaceted functions support …

The quality of oocytes declines by aging, resulting in their low competences for fertility. Here,
resveratrol treatment showed increases in the rates of implantation and live offspring as well …

Mammalian follicles are constituted of a complex structure composed of several layers of
granulosa cells surrounding the oocyte and of theca cells that reside beneath its basement …