The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

Obesity is a complex, chronic medical condition with a major negative impact on human
health. 1 Over the last 30 years, there has been an exponential growth in the prevalence of …

Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …

Over the past several years, the field of cancer research has directed increased interest
towards subsets of obesity-associated tumours, which include mammary, renal …

Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …

Cancer-associated fibroblasts (CAF) comprise the majority of stromal cells in breast cancers,
yet their precise origins and relative functional contributions to malignant progression …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …