The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

Aplastic anemia (AA) is a T cell–mediated autoimmune disorder of the hematopoietic system
manifested by severe depletion of the hematopoietic stem and progenitor cells (HSPCs) …

Tumor‐associated macrophages (TAMs) in solid tumors exert protumor activities by
releasing cytokines or growth factors into the tumor microenvironment. Increasing studies …

Protein–protein interactions (PPIs) are fundamental to many biological processes that play
an important role in the occurrence and development of a variety of diseases. Targeting the …

Integrins were originally identified as receptors for extracellular matrix (ECM) and cell-
surface molecules (eg, VCAM-1 and ICAM-1). Later, we discovered that many soluble …

Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much
value for prospective biomarker discovery studies, and protocols that offer high throughput …

Background Ezrin-radixin-moesin (ERM) have been explored in many cancer processes.
Moesin, as its component, has also been found to play an important role in the prognosis of …

Background Cashmere has long been used as the raw material for wool textiles. The
diameter of the cashmere fibre determines its quality and economic value. However, the …

Recognition of integrins by CD62P has not been reported and this motivated a docking
simulation using integrin αvβ3 as a target. We predicted that the C-type lectin domain of …