Background Metformin is widely used in the treatment of diabetes, and there is interest in
'repurposing'the drug for cancer prevention or treatment. However, the mechanism …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

Patients with diabetes mellitus are at increased risk of cancer development. Metformin is a
well-established, effective agent for the management of type 2 diabetes mellitus …

Simple Summary Diabetes mellitus is a common disease in patients with cancer. It is a risk
factor for certain cancers such as pancreatic, liver, colon, breast, and endometrial cancer …

Immunotherapy has matured into standard treatment for several cancers, but much remains
to be done to extend the reach of its effectiveness particularly to cancers that are resistant …

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …

Type 2 diabetes (T2D) is a heterogeneous complex disease affecting more than 29 million
Americans alone with a rising prevalence trending toward steady increases in the coming …

The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …

Background We previously reported that the incidence of hepatocellular carcinoma (HCC)
with non-viral etiologies increased rapidly between 1991 and 2010 in Japan. Methods To …

The American Diabetes Association (ADA)“Standards of Medical Care in Diabetes” includes
the ADA's current clinical practice recommendations and is intended to provide the …