The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …

Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …

Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …

Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the …

Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of
neutrophils. MPO utilizes H 2 O 2 to generate hypochlorous acid (HClO) and other reactive …

It is becoming increasingly clear that neuroinflammation has a causal role in the
pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic …