Pharmacogenetics and pain treatment with a focus on non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants: a systematic review
F Zobdeh, II Eremenko, MA Akan, VV Tarasov… - Pharmaceutics, 2022 - mdpi.com
Background: This systematic review summarizes the impact of pharmacogenetics on the
effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants …
effect and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants …
[HTML][HTML] IL-33/ST2 signaling in pain and itch: Cellular and molecular mechanisms and therapeutic potentials
P Li, Q Yu, H Nie, C Yin, B Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Pain is a cardinal feature of many diseases. Chronic pain poses heavy burdens to the
suffering patients, both physically and mentally. However, current mainstream medications …
suffering patients, both physically and mentally. However, current mainstream medications …
A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism
Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food
origin, and their highly polymorphic nature concurs with the diverse inter-individual …
origin, and their highly polymorphic nature concurs with the diverse inter-individual …
An update on postoperative respiratory depression
TN Weingarten, J Sprung - International Anesthesiology Clinics, 2022 - journals.lww.com
The last 2 decades have witnessed dramatic swings in the perioperative use of analgesic
medications. The concept of pain as the fifth vital sign and regulatory emphasis on adequate …
medications. The concept of pain as the fifth vital sign and regulatory emphasis on adequate …
Opioid Monitoring in Clinical Settings: Strategies and Implications of Tailored Approaches for Therapy
LM Rosendo, T Rosado, T Zandonai, K Rincon… - International Journal of …, 2024 - mdpi.com
This review emphasises the importance of opioid monitoring in clinical practice and
advocates for a personalised approach based on pharmacogenetics. Beyond effectively …
advocates for a personalised approach based on pharmacogenetics. Beyond effectively …
An overview of the use and misuse/abuse of opioid analgesics in different world regions and future perspectives
V Mayoral - Pain Management, 2022 - Future Medicine
Opioids are an important therapeutic option for severe resistant chronic pain but, in the
absence of proper oversight, their use has risks. The level of prescription opioid …
absence of proper oversight, their use has risks. The level of prescription opioid …
Pharmacogenetics of lethal opioid overdose: review of current evidence and preliminary results from a pilot study
L Magarbeh, I Gorbovskaya, R Wells, R Jhirad… - Journal of personalized …, 2023 - mdpi.com
There has been a worldwide substantial increase in accidental opioid-overdose deaths. The
aim of this review, along with preliminary results from our pilot study, is to highlight the use of …
aim of this review, along with preliminary results from our pilot study, is to highlight the use of …
Pharmacogenomics in allogeneic hematopoietic stem cell transplantation: Implications on supportive therapies and conditioning regimens
SA Morris, DG Nguyen, JN Patel - Best Practice & Research Clinical …, 2023 - Elsevier
Allogeneic hematopoietic stem cell transplantation mortality has declined over the years,
though prevention and management of treatment-related toxicities and post-transplant …
though prevention and management of treatment-related toxicities and post-transplant …
Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients
ML Shannon, A Muhammad, NT James… - Clinical and …, 2023 - Wiley Online Library
Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently
rely on only a few high effect variants. Quantification of the polygenic contribution to …
rely on only a few high effect variants. Quantification of the polygenic contribution to …
Residents' Knowledge regarding Recreational Drug Screening Immunoassays at a Swiss Hospital Group
E Bekka, SE Christen, L Hermann… - … Journal of Analytical …, 2024 - Wiley Online Library
Introduction. In case of suspected acute recreational drug toxicity, immunoassays are
commonly used as diagnostic tools. Although easy to handle, understanding of their …
commonly used as diagnostic tools. Although easy to handle, understanding of their …