In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …

Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is
characterized by neurobehavioural comorbidities due to dystrophin deficiency in the brain …

We have used FRET-based biosensors in live cells, in a robust high-throughput screening
(HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac …

Muscular dystrophies (MDs) are heterogeneous diseases, characterized by primary wasting
of skeletal muscle, which in severe cases, such as Duchenne Muscular Dystrophy (DMD) …

A decrease in skeletal muscle contractile activity or its complete cessation (muscle
unloading or disuse) leads to muscle fibers' atrophy and to alterations in muscle …

Parkinson's disease is one of the most common neurodegenerative diseases affecting the
ageing population, with a prevalence that has doubled over the last 30 years. As the …

Sarcopenia is a geriatric syndrome characterized by an age‐related decline in skeletal
muscle mass and strength. Here, we show that suppression of mitochondrial calcium …

Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the
alterations to systemic metabolism manifested in DMD patients contribute to the severe …

High‐intensity exercise stimulates glycolysis, subsequently leading to elevated lactate
production within skeletal muscle. While lactate produced within the muscle is …