Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Interaction between macrophages and ferroptosis

Y Yang, Y Wang, L Guo, W Gao, TL Tang, M Yan - Cell death & disease, 2022 - nature.com
Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid
peroxidation and GSH depletion mediated by iron metabolism and is morphologically …

[HTML][HTML] System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation

W Yang, Y Wang, C Zhang, Y Huang, J Yu… - Frontiers in …, 2022 - frontiersin.org
Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause
acute liver injury (ALI). ALI can further develop into serious liver diseases such as cirrhosis …

Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

L Feng, K Zhao, L Sun, X Yin, J Zhang, C Liu… - Journal of Translational …, 2021 - Springer
Background Solute carrier family 7 member 11 (SLC7A11) is a component of
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …

Non-coding RNAs and ferroptosis: potential implications for cancer therapy

A Balihodzic, F Prinz, MA Dengler, GA Calin… - Cell Death & …, 2022 - nature.com
Ferroptosis is a recently defined form of regulated cell death, which is biochemically and
morphologically distinct from traditional forms of programmed cell death such as apoptosis …

Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes

X Wang, Z Liu, P Peng, Z Gong, J Huang… - Chemico-biological …, 2022 - Elsevier
Ferroptosis is a novel form of regulated cell death that has a close association with
mitochondrial dysfunction and is characterized by iron overload, the accumulation of …

Regulatory pathways and drugs associated with ferroptosis in tumors

D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …