To achieve the pH-responsive release of metformin in tumor acidic microenvironment, we
prepared OHA-Met by covalently grafting metformin (Met) onto oxidized hyaluronic acid …

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. As a type of
CVDs, myocardial infarction (MI) induces ischemia hypoxia, which leads to excessive …

Hepatocellular carcinoma (HCC) is the most familiar primary hepatic malignancy with a poor
prognosis. The incidence of HCC and the associated deaths have risen in recent decades …

Cancer resistance to anti-tumour agents has been one of the serious challenges in different
types of cancer treatment. Usually, an increase in the cell death markers can predict a higher …

Ferroptosis is a recently recognized form of non-apoptotic regulated cell death and usually
driven by iron-dependent lipid peroxidation and has arisen to play a significant role in …

Iron participates in myriad processes necessary to sustain life. During the past decades,
great efforts have been made to understand iron regulation and function in health and …

Ferroptosis featured by iron‐dependent lipid peroxidation plays a critical role in tumor
regression, offering an alternative therapeutic target for the treatment of aggressive triple …

Simple Summary Strikingly, there are many literature reports confirming that the SLC7A11
gene is closely related to the tumourigenesis, survival, proliferation, metastasis, therapeutic …

Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast
cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer …

Background The dysregulated mechanistic target of rapamycin complex 1 (mTORC1)
signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the …