The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD).
Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in …

Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …

Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …