The aim of this review is to present evidence of the impact of ischemic changes in the blood–
brain barrier on the maturation of post-ischemic brain neurodegeneration with features of …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Background Cerebral amyloid angiopathy (CAA) is a devastating condition common in
patients with Alzheimer's disease but also observed in the general population. Vascular …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

White matter (WM) disease is associated with disruption of the gliovascular unit, which
involves breach of the blood–brain barrier (BBB). We quantified pericytes as components of …

The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …

Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

Key points Preclinical models have demonstrated that nitric oxide is a key component of
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …