Abstract Purpose of Review The intricate interplay between inflammatory and reparative
responses in the context of heart injury is central to the pathogenesis of heart failure. Recent …

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Inflammation is a common feature in neurodegenerative diseases that contributes to
neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed …

Basophils bind IgE via FcεRI-αβγ 2, which they uniquely share only with mast cells. In doing
so, they can rapidly release mediators that are hallmark of allergic disease. This …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

N-formyl peptide receptors (FPRs) are seven-transmembrane, G protein-coupled receptors
with a wide distribution in immune and non-immune cells, recognizing N-formyl peptides …

The spleen contributes importantly to myocardial ischemia/reperfusion (MI/R) injury.
Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 …

Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease that is
characterized by vascular remodeling of the pulmonary artery. Pulmonary vascular …

Background Timely and proper suppression of inflammation can effectively reduce
myocardial injury and promote the postmyocardial infarction (post-MI) wound-healing …

Cardiac fibrosis is defined as excessive deposition of extracellular matrix (ECM) in
pathological conditions. Cardiac fibroblasts (CFs) activated by injury or inflammation …